Partner 2. Forschungszentrum Rossendorf (FZR-Dresden)
Institut für Kern- und Hadronenphysik
PO Box 510119 - 01314 Dresden - Germany

Scientific team

Name	Position		Task
E. Grosse	full professor		team leader
M. Sczepan	post-doc		IR-spectroscopy and microscopy
R. Wünsch	scientific staff		numerical simulations
W. Seidel	scientific staff		IR experiments
D. Wohlfarth	scientific staff		radiation transport
U. Wolf	engineer		computer control
M. Tecimer	PhD student		cavity ring down experiments
G. Furlinski	PhD student		IR-spectroscopy and microscopy
P. Evtushenko	PhD student		free-electron-laser diagnostics

Objectives
The Radiation Source ELBE at Dresden-Rossendorf is centered around a superconducting Electron accelerator of high Brilliance and low Emittance (ELBE), constructed to produce up to 40 MeV electron beams of 1mA at 100% duty cycle. This new facility will deliver secondary beams of different kind starting in the year 2001 and it will allow biomedical studies to be performed with intensive tunable quasi-monochromatic radiation in different spectral regions. Special emphasis at ELBE will be given to the production of intense high-brilliance infrared (IR) radiation from Free-Electron-Laser (FEL) devices. The IR as produced in the FEL will cover the range from the near IR (0.004 mm) to microwaves in the 1 to 10 THz-regime with a high pulse energy (>500 nJ) and average power (>10W). A simultaneous application of FEL infrared light and other wavelengths - also from conventional lasers synchronized to the FEL - will be possible. ELBE is designed as a user facility open for scientists from different fields and different institutions and thus various irradiation studies envisaged in THz-BRIDGE may take place at ELBE starting in 2001. The current activities related to the research on radiation effects are very well matched to past and ongoing work with ionizing radiation penetrating biological material; this has the big advantage that important expertise and equipment
- as e.g. a cell laboratory - is already available.

Workplan
The biomedical research activities are concentrated in the Radiation Physics and the Free-Electron-Laser departments of the Institute for Nuclear and Hadron Physics. These two departments closely work together in setting-up equipment for investigations of biomedical nature at two radiation stations - the IR-FEL radiation as well as the channeling X-ray source; they especially will collaborate in the probe preparation and in the use of a rather modern cell laboratory. Besides delivering the high power beams in the final stage of the project the FZR team will take the responsibility of spectroscopy measurements at the existing FEL facilities at LURE (F) and FELIX (NL).

The FZR-Dresden team will mainly contribute to the project workpackages as described below:

Workpackage 1 (34 person-months)
WP-1 is mainly devoted to spectroscopic investigations of biological samples in the range 100 GHz to 20 THz. FZR will make first test irradiations at 30 THz and below using high power gas lasers. Starting in 2001 its spectroscopy equipment at the ELBE-mIR-FEL will be available for measurements in the range down to 10 THz. For lower frequencies a waveguide system will be developed to optimize the FEL emission and the irradiations with it. Parallel to these developments irradiations at LURE-CLIO and at FELIX are envisaged and will be proposed to the respective user committees. In addition to the basic spectroscopic studies with monochromatic FEL-radiation at ELBE an existing Fourier-Transform IR-spectrometer will be used by FZR to perform spectroscopic survey studies to generate a database.

Workpackage 2 (20 person-months)
For the evaluation of biological effects from irradiations with THz radiation the high intensity 2nd stage of ELBE has to be operable. Then frequencies down to 3 THz will be available at Rossendorf with sufficient power. For such investigations a proper waveguiding system is essential for the production and application of the radiation. Numerical studies for the optimisation of waveguides are under way and experimental tests of such equipment will start early in 2001. Irradiations of biological probes (like tissue and cells) will become possible in 2002.

Workpackage 3 (2 person-months)
In addition to the above studies FZR-Dresden will support CRL/TREL in the preparation of a survey on exposure conditions at specific sites where THz-radiation is used.